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ISI is the leader in neuroendocrine tumors (NET's) Biomarker Testing

Neuroendocrine Tumors: A Comprehensive Guide to Diagnosis and ManagementCelebrating its 44th year of continued cutting edge esoteric services to the medical, research and academic communities, Inter Science Institute specializes in research and development emphasis in the area of Neuroendocrine Tumors (NET's). The current 5th edition handbook, Neuroendocrine Tumors: A Comprehensive Guide to Diagnosis and Management, is available for download on this website or by contacting ISI at

Click here for the previous edition.

5-HIAA assay is now available on plasma (Z-tubeTM) from ISI

New test available for patients: the 5-HIAA assay is now available on plasma (Z-tubeTM) from ISI. Click here to see the requirements.

ISI's Latest Journal Publications are Available

A Single Fasting Plasma 5-HIAA Value Correlates With 24-Hour Urinary 5-HIAA Values and Other Biomarkers in Midgut Neuroendocrine Tumors (NETs)

5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine more.

A Prospective Evaluation of the Effect of Chronic Proton Pump Inhibitor Use on Plasma Biomarker Levels in Humans

Proton pump inhibitors (PPIs) are used primarily to treat gastroesophageal reflux disease. Proton pump inhibitorYinduced achlorhydria increases circulating gastrin and chromogranin A (CGA). Chromogranin is a widely used biomarker for the diagnosis and follow-up for gut-based neuroendocrine tumors (NETs) more.

Serum Pancreastatin - The Long Sought Universal, Sensitive, Specific Tumor Marker for Neuroendocrine Tumors?

One of the principal priorities identified at the National Cancer Institute summit for improving the management of neuroendocrine tumors ([NETs] pancreatic endocrine tumors and carcinoids) was the need to identify tumor markers that could be used for early diagnosis and more.

C.U.R.E.® Catalogue

The C.U.R.E.® Catalogue lists over 150 individual assays, that can be performed on plasma/serum, urine, CSF, Saliva, and other fluids in the areas of:

G.I. & Pancreatic Tests
Hypertension, Corticosteroid, & Mineralocorticoid Tests
Hypothalamic-pituitary Axis & Releasing Factor Tests
Multi-disciiplinary Tests
Pediatric & Enzyme Deficiency Tests
Reproductive Endocrinology & Gonadal Steroid Tests
Thyroid Tests

Please contact ISI for the most up to date testing availability.

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For the Most Recent Edition of the C.U.R.E.® (Current Unique and Rare Endocrine) Catalogue please contact the Institute at:


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