Code Details for Lab and Clinical Services
ISI Order Code: GIP
CPT Code: 83520
Clinical Significance of GIP
Gastric Inhibitory Polypeptide (GIP) is a 43 amino acid peptide structurally related to Glucagon and Secretin and is found in the mucosa of upper intestine produced by K-Cells. GIP was originally detected as a factor inhibiting the secretion of gastric acid and Gastrin secretion. Its major action has now been determined to be a potent stimulant of B-Cells to release Insulin and is also known as Glucose-Dependent Insulinotropic Peptide.
Exaggerated increases in GIP are noted after glucose administration to patients with Pancreatitis. This increase is also seen in patients with Diabetes Mellitus. GIP levels are decreased by Calcitonin. Elevated levels are present in cases of Verner-Morrison’s Syndrome.
Reference Range, Procedure & Expected Results
Reference Range:
11.0 – 66.6 pg/mL
Procedure:
Glucagon is measured by an immunoassay.
Expected Turnaround Time:
10 Business Days
Turnaround time is defined as the usual number of days from the date of receipt of a specimen for testing to when the result is released to the ordering facility.Report: Sample Report
Patient Preparation Guidelines
Patient is preferred to be fasting for 10 – 12 hours prior to collection of specimen. Patient should not be on any antacid medications or medications that affect intestinal motility, if possible, for at least 48 hours prior to collection.
Specimen Collection:
Collect 10mL blood in the special ISI GI preservative tube filling tube completely and separate as soon as possible. Freeze specimen immediately after separation. Special GI preservative tubes are available from Inter Science.
Minimum specimen size is 1 mL.
Please contact ISI for separation using a non refrigerated centrifuge. Contact ISI for details.
The Inter Science Institute GI Preservative collection and preservative tube is intended for use with Inter Science Institute’s Cholecystokinin (CCK), Ghrelin, GLP-1, Peptide YY (PYY), Secretin, Somatostatin, and VIP assays only. It has not been validated for use with other in vitro assays. Effects of using this device other than as intended are unknown, and is not recommended.
Important Precautions
Gastric Inhibitory Polypeptide specimens must be collected using the GI Preservative tube. No other specimens are acceptable.
For Research Use Only. Not for use in diagnostic procedures.
Rejection Criteria:
- Gross hemolysis/lipemia/icteric
Shipping and Handling Instructions for GIP Assay Specimens
Shipping Instructions:
Gross hemolysis/lipemia/icteric
Research & Scientific References
- 1. T Krarup. Immunoreactive Gastric Inhibitory Polypeptide. Endocrine Reviews 9: 122, 1988.
- 2. DL Sarson, MG Bryant, and SR Bloom. A Radioimmunoassay of Gastric Inhibitory Polypeptide in Human Plasma. Journal of Endocrinology 85: 487, 1980.