ISI Order Code: MLN
CPT Code: 83519
Clinical Significance:
Motilin is a 22 amino acid peptide produced primarily by the enterochromaffin cells (EC2 or M cells) in the intestine, duodenum and the jejunum. It is absent from the stomach and colon. It accelerates gastric emptying and colonic motor activity, and stimulates the feeding response. It has no structural similarities with other gastrointestinal peptides and has short half-life of approximately five minutes. Motilin secretion can be stimulated by acid and a fat-rich meal as it can increase the secretion of Pepsin and causes increased intra-gastric pressure. It also stimulates lower esophageal sphincter contraction. Motilin levels are suppressed by Calcitonin.
Reference Range:
Up to 446 pg/ml
Procedure:
Motilin is measured by direct radioimmunoassay.
Expected Turnaround Time: 14 Business Days
Turnaround time is defined as the usual number of days from the date of receipt of a specimen for testing to when the result is released to the ordering facility.
Report: Sample Report
Patient Preparation:
Patient should be fasting 10 – 12 hours prior to collection of specimen. Patient should not be on any antacid medication or medications affecting intestinal motility, if possible, for at least 48 hours prior to collection.
Specimen Collection:
3 ml serum or EDTA plasma should be collected and separated as soon as possible. Freeze specimens immediately after separation. Minimum specimen size is 1 ml.
Rejection Criteria: Gross hemolysis/lipemia/icteric
Special Specimens:
For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.
Shipping Instructions:
Ship specimens frozen in dry ice.
References:
1. D Dea, G Boileau, P Poitras, and RG Lahaie. Molecular Heterogeneity of Human Motilin Like Immunoreactivity Explained by the Processing of Prepromotilin. Gastroenterology 96: 695, 1989.
2. ND Christofides, SR Bloom, and G vanTrappen. Postprandial Release of Motilin in Relation to the Interdigestive Motor Complex in Man. Biomedical Research 2: 67, 1981.